Click Here to return To Results

 

Specific Learning Disability in Children with Neurofibromatosis Type 1:Significance of MRI Abnormalities Neurol 44:878-883, North,K.,et al, 1994 See this aricle in Pubmed Article Abstract To determine whether previously reported areas of increased T2 signal intensity of MRI examination in children with neurofibromatosis type 1(NF 1)are associated with deficits in development and learning common in this population,we evaluated 51 children with NF 1(aged 8 to 16 years).Children with areas of increased T2 signal intensity were at a much higher risk for impaired academic achievement.Children without increased T2 signal on MRI (UBO-)did not significantly differ from the general population in any measure of ability or performance.Areas of increased T2 signal on MRI represent dysplastic glial proliferation and aberrant myelination in the developing brain and are associated with deficits in higher cognitive function.The presence of these abnormal signals on MRI divides the NF 1 population into two distinct groups anatomically and developmentally(UBO+ and UBO-).These two groups should be considered separately in the assessment and management of learning disability in children with NF 1.

Related Tags

(click to filter results - removes previous filter) developmental disability intellectual deficit learning disability learning disability,in children MRI MRI,abnormal MRI,high signal foci on neurofibromatosis 1

Click Here to return To Results